Crystal structure of the Bacillus stearothermophilus pcrA DNA helicase

Complex with DNA, ADPNP (non-cleavable ATP analog), showing helicase motifs

Subrananya et al. 1996. Nature 384:379-383.
Velankar et al. 1999. Cell 97:75-84.
Yellow:GKS/T of motif I
bxGxPGxGKS/Txxb)
Purple:DE of motif II
(bbbDEb)
Red:GD of motif III
(bbbbGDxxQ)
Green:Y of motif IV
Violet:QG (actually KG) of motif V
(TbxxxQGxTbxxVxbb)
Blue:ITR of motif VI
(bVAuTR)
 
b = bulky hydrophobic, aliphatic or aromatic
u = bulky aliphatic
x = any amino acid
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C terminal structure Residues identical among
   PCRA and nsP2 of SIN, SFV, RRV, ONN
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