Crystal structure of the hepatitis C virus NS3 helicase

complexed with oligo-dU8.
Kim et al. (1998) Structure 6:89-100.

Helicase motifs
Yellow:GKS of motif I
(b2x4GSGKS/Tx3bP)
Purple:DE of motif II
(bbbBDExH)
Red:AT of motif III
(bxuTATPP)
Green: LIF of motif IV
(GD/NuL/VI/VF)
Violet:TD of motif V
(bubxTDbxExGuxbx4u2)
Blue:QR of motif VI
(Tx5QRxGRuGR)
 
b = bulky hydrophobic, aliphatic or aromatic
u = bulky aliphatic
x = any amino acid
Oligo-dU8 is CPK colored.
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protein-DNA contacts
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