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Sondra SchlesingerProfessorPhone, office: (314)-362-2746 Phone, lab: (314)-362-2745 FAX: (314)-362-1232 email: sondra@borcim.wustl.edu 519 McDonnell Science Building
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PUBLICATIONS: From 1996
Frolov, I. and Schlesinger, S. (1996) Translation of Sindbis virus
mRNA: Analysis of sequences downstream of the initiating AUG codon
that enhance translation.
J. Virol. 70: 1182-1190.
Frolov, I, Hoffman, T.A., Pra´gai, B.M., Dryga, S.A., Huang, H.V., Schlesinger, S. and Rice, C.M. (1996) Alphavirus-based expression vectors: strategies and applications. Proc. Natl. Acad. Sci. USA 93: 11371 - 11377.
Frolova, E., Folov, I. and Schlesinger, S. (1997) Packaging Signals in Alphaviruses. J. Virol: 71: 248-258.
Dryga, S.A., Dryga, O.A. and Schlesinger, S. (1997) Identification of mutations in a Sindbis virus variant able to establish persistent infection in BHK cells: the importance of a mutation in the nsP2 gene. Virology 228: 74-83.
Frolov, I., Frolova, E. and Schlesinger, S. (1997) Sindbis virus replicons and Sindbis virus: assembly of chimeras and of particles deficient in virus RNA. J. Virol. 71:2819-2829.
Schlesinger, S. (1997) Bernard N. Fields - a biographical memoir. in Biographical Memoirs, 1997 The National Academy Press, Washington, D.C.
Agapov, E.V. Frolov, I., Lindenbach, B.D., Pragal, B.M., Schlesinger, S. and Rice, C.M.(1998) Noncytopathic Sindbis virus RNA vectors for heterologous gene expression. Proc. Natl. Acad. Sci. USA 95: 12989-112994.
Olivo, P.D., Collins, P.L., Peeples, M.E. and Schlesinger, S. (1998)
Detection and quantitation of human respiratory syncytial virus (RSV) using
minigenome cDNA and a Sindbis virus replicon: a prototype assay for
negative-strand RNA viruses. Virology 251: 198-205.
Ivanova, L., Schlesinger, S. and Olivo, P.D. (1999) Regulated expression
of a Sindbis virus replicon by herpesvirus promoters. J. Virol. 73:
1998-2005.
Frolov, I., Agapov, E., Hoffman, T.A. jr., Pragai, B.M., Lippa, M.,
Schlesinger, S. and Rice, C.M. (1999) Selection of RNA replicons capable
of persistent non-cytopathic replication in mammalian cells. J. Virol.
73: 3854-3865.
Polo JM, Belli BA, Driver DA, Frolov I, Sherrill S, Hariharan MJ, Townsend
K, Perri S, Mento SJ, Jolly DJ, Chang SM, Schlesinger S, Dubensky TW, Jr.
(1999) Stable alphavirus packaging cell lines for Sindbis virus and Semliki
Forest virus-derived vectors. Proc Natl Acad Sci USA 96:4598-4603.
Ehrengruber MU, Lundstrom K, Schweitzer C, Heuss C, Schlesinger S, Gähwiler BH: (1999) Recombinant Semliki Forest virus and Sindbis virus efficiently infect neurons in Hippocampal slice cultures. Proc. Natl. Acad. Sci. USA 96:. 7041-7046.
Schlesinger, S. (1999) Alphavirus expression systems -promises and problems. ASM News 65: 688-695.
Schlesinger, S and Dubensky, T.W. Jr. (1999) Alphavirus vectors for gene expression and vaccines, Current Opinion in Biotechnology, 10: 434-439.
Schlesinger, S. (2000) Alphavirus expression vectors in Advances in Virus Research Academic Press 55: 565-577.
Schlesinger, S. and Schlesinger, M.J. Replication of Togaviridae in FIELDSVIROLOGY, fourth edition Lipincott - Raven Press, Philadelphia
Schlesinger S. (2001) Alphavirus vectors: development and potential therapeutic applications invited review for Expert Opinion on Biological Therapy 1: 177-191, 2001.
Web publication: http://medicine.wustl.edu/virology/
PATENTS
Sindbis virus vectors: Patent number 5, 091,309 - with Henry V. Huang, Robin Levis, Barbara Weiss and Manuel Tsiang
Infectious Sindbis virus vectors: Patent number 5,2217,879 - with Henry V. Huang, Robin Levis, Charles M. Rice, Ping Shen and Cheng Xiong
Indicator Cell lines for detecting RNA viruses: Patent number 5,591,579 - with Paul Olivo
Silent inducible promoters and uses thereof Patent number 6,136,538
Detection of Negative-Strand viruses Patent number 6,270,958
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